Liming Wang, California State University at Los Angeles

Noise Attenuation in Feedback Systems

Feedback modules, which appear ubiquitously in biological regulations, are often subject to disturbances from the input, leading to fluctuations in the output.  What are the functions of feedback loops?  Why are there often multiple feedback loops in biological systems?  Do they affect a system's noise property?  In this talk, we will explore these questions by introducing a critical quantity: SAT (the signed activation time) that dictates the noise attenuation capability in feedback systems.  Our findings suggest that the relationship between the noise amplification rate and SAT could be a general principle for many biological systems regardless of specific regulations or feedback loops.