Some core CIMS faculty has a substantial record for interaction with industry (Advanced Light Source, Euclid, Honeywell, IBM, Numerica, and Tech X Corporation), government agencies (US Forest Service, Environmental Protection Agency, Bureau of Labor Statistics, US Department of Agriculture), and national research centers and laboratories (National Center for Atmospheric Research, National Institute of Standards and Technology, Centers for Disease Control and Prevention, Argonne National Laboratory, Idaho National Laboratory, Lawrence Berkeley National Laboratory, Lawrence Livermore National Laboratory and Los Alamos National Laboratory). These interactions have led to numerous funded contracts and grants as well as patent applications and disclosures on high-dimensional data analysis and image processing, and a Small Business Innovation Research grant awarded to Numerica Corporation in May, 2007. CIMS core faculty have also had direct impact on the development of a number of widely distributed public scientific computing software packages.

Together these CIMS-related activities have substantial impact on the economy of Colorado and the nation, by enhancing CSU's research infrastructure, by increasing CSU's visibility, and by transferring technology to industry and government. In addition to the long-term economic impacts of research and technology transfer, CIMS has more immediate impacts by bringing in visitors, workshops, and large amounts of grant funding to Colorado State.