Amit Joshi, Wolfgang Bangerth,
Eva M. Sevick-Muraca
Non-contact fluorescence optical tomography with scanning area
illumination
Proceedings of the IEEE International Symposium on
Biomedical Imaging, Arlington, VA, 2006, pp. 582-585.
This contribution describes a novel non-contact fluorescence
optical tomography scheme which utilizes multiple area illumination
patterns, to reduce the illposedness of the inverse
problem involved in recovering interior fluorescence yield distribution
in biological tissue from boundary fluorescence measurements.
Multiple excitation source illumination patterns
are simulated by gaussian beam sources scanning the simulated
tissue phantom surface. Area measurements of fluorescence
amplitude and phase are collected on the illumination
plane. Multiple measurement data sets generated by scanning
the excitation sources are processed simultaneously to
generate the interior fluorescence distribution in tissue by implementing
a dual adaptive finite element based fluorescence
tomography algorithm in a parallel framework suitable for
multiprocessor computers. Image reconstructions for multiple
fluorescent targets (5mm diameter) embedded in a 512ml
simulated tissue phantom are demonstrated.
Wolfgang Bangerth
Sun Mar 3 06:42:12 MST 2024